The Renal Protective Effect of Glycyrrhiza Glabra Against Renal Injury Induced by CCl4 in Male Rats

Abstract

     

Glycyrrhiza Glabra (Licorice), is a widely used medicinal plant known for its anti-inflammatory, anti-oxidative, and anti-bacterial properties. While its therapeutic effects have been explored in various systems, its potential nephroprotective role remains inconclusive. This study aimed to evaluate the effect of aqueous G. glabra root extract on carbon tetrachloride (CCl₄)-induced nephrotoxicity in male Wistar rats. Male Wistar rats 120-200g were separated into four groups (N=6). Group I remained untreated. Group II and Group III received 0.8 ml/kg of CCl4 subcutaneously for regular 21 days. Group III and additionally Group IV received 30 mg/Kg of aqueous licorice extract was administered orally via gavage daily for a period of 21 days. On the 22nd day, animals were euthanized and blood samples were collected for biochemical testing. The increase in the final weight of group I (control) and group IV (glycyrrhiza glabra treated group), whereas, a decrease in group II (CCl4 treated) and group III (CCl4 + glycyrrhiza glabra treated) has been recorded. The level of urea, creatinine, and BUN increased in groups II, III, and IV. The lipid profile test showed a decreased cholesterol level in groups II, III, and IV. The HDL is decreased and LDL is increased in groups II, III, and IV. It can be concluded that the given dosage of glycyrrhiza glabra does not show nephroprotective effects against carbon tetrachloride toxicity.